RNA Interference Technologies and Therapeutics
نویسندگان
چکیده
منابع مشابه
Ethical Perspectives on RNA Interference Therapeutics
RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer, infectious diseases and metabolic disorders. Clinical trials with RNA interference have begun. However, challenges such as off-target effects, toxicity and safe delivery methods have to be overcome before...
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RNA interference (RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism in animals and plants, which is mediated by double-stranded RNA (dsRNA). There has recently been an increasing interest in harnessing the gene silencing activity of dsRNA to develop novel drugs for the treatment of various diseases, such as cancer, neurol...
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The central dogma of biology describes the transfer of biological information from DNA through to protein (Crick, 1970). In the first phase, known as transcription, DNA is converted into a complementary sequence of messenger RNA (mRNA). This mRNA allows the genetic message to be communicated outside of the nucleus, to other areas of the cell, where it is then translated into protein by ribosome...
متن کاملRNA interference: from gene silencing to gene-specific therapeutics.
In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RNA (dsRNA) reagents are used to bind to and promote the degradation of target RNAs, resulting in k...
متن کاملPossibilities for RNA Interference in Developing Hepatitis C Virus Therapeutics
The discovery and characterization of the RNA interference (RNAi) pathway has been one of the most important scientific developments of the last 12 years. RNAi is a cellular pathway wherein small RNAs control the expression of genes by either degrading homologous RNAs or preventing the translation of RNAs with partial homology. It has impacted basic biology on two major fronts. The first is the...
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ژورنال
عنوان ژورنال: BioDrugs
سال: 2009
ISSN: 1173-8804
DOI: 10.2165/11318190-000000000-00000